Nonsense-Mediated mRNA Decay: Pathologies and the Potential for Novel Therapeutics

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Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation terminat...

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Nonsense-mediated mRNA decay

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Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact.

Nonsense-mediated mRNA decay (NMD) was originally coined to define a quality control mechanism that targets mRNAs with truncated open reading frames due to the presence of a premature termination codon. Meanwhile, it became clear that NMD has a much broader impact on gene expression and additional biological functions beyond quality control are continuously being discovered. We review here the ...

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ژورنال

عنوان ژورنال: Cancers

سال: 2020

ISSN: 2072-6694

DOI: 10.3390/cancers12030765